Nucleus accumbens acetylcholine and feeding 1 RUNNING HEAD: Nucleus accumbens acetylcholine and feeding Nucleus accumbens acetylcholine and food intake: Decreased muscarinic tone reduces feeding but not food-seeking
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چکیده
Wayne E. Pratt Kaitlin Blackstone Department of Psychology Wake Forest University NOTICE: this is the author’s version of a work that was accepted for publication. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in:
منابع مشابه
Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors.
These experiments tested whether nucleus accumbens muscarinic or nicotinic acetylcholine receptor activation is required for rats to learn to lever press for sucrose. Muscarinic blockade with scopolamine (1.0 microg/side or 10.0 microg/side), but not nicotinic antagonism with mecamylamine (10.0 microg/side), inhibited learning and performance when applied to the core or shell. Further experimen...
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Introduction: The role of different parts of the extended amygdala in metabolic signs of stress is not well understood. In the present study, we decided to evaluate the impact of the shell part of nucleus accumbens (NAc) on metabolic disturbance induced by electro foot shock stress using transient inactivation method in the rat. Methods: Male Wistar rats (W: 230-250 g) were canuulated un...
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Background: Ascorbic acid (AA) is not synthesized in the brain but it is actively transported through blood-brain barrier by SVCT2 cotransporter and it is stored in high concentrations with heterogeneous distribution in areas such as nucleus accumbens shell (AcbSh) in the mammalian brain. Previous studies have shown that Ascorbic acid injection into AcbSh decreases feeding therefore, in the pre...
متن کاملDissimilarities between cholinergic and dopaminergic turning elicited by nucleus accumbens stimulation in freely moving rats.
Contralateral turning was produced by unilateral injection of carbachol (0.5, 2.5, 5 micrograms) into the nucleus accumbens, but not into the dorsal or ventral striatum. This behaviour was inhibited by muscarinic M1 acetylcholine receptor blockade in the nucleus accumbens, and less effectively by blockade of muscarinic M2 and nicotinic acetylcholine receptors. Unilateral injection of a mixture ...
متن کاملRole of NO-ergic system of the he nucleus accumbens in metabolic disturbances under acute stress
Introduction: The aim of the study was to evaluate the involvement of nitricergic system within the shell part of the nucleus accumbens (NAc) by injection of L-arginine, a nitric oxide precursor, and L NAME, a nitric oxide synthase inhibitor in the metabolic disturbances induced by acute stress in the male rat. Materials and Methods: Male Wistar rats were cannulated unilaterally in the left par...
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